Silicon Foliar Fertilisation Ameliorates Olive Leaves Polyphenolic Compounds Levels and Elevates Its Potential towards Different Cancer Cells

It is not yet clear how adding silicon foliar fertilisation affects olive leaf (OL) phenolics and their potential to impact different cancer cells. Thus, we conducted a field trial to study the effect of foliar Si biostimulant fertilisation on the OL phenolic content of the ‘Leccino’ (LE) and ‘Istar...

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Published inApplied sciences Vol. 14; no. 11; p. 4669
Main Authors Pasković, Igor, Franić, Mario, Polić Pasković, Marija, Talhaoui, Nassima, Marcelić, Šime, Lukić, Igor, Fredotović, Željana, Žurga, Paula, Major, Nikola, Goreta Ban, Smiljana, Vidović, Nikolina, Rončević, Sanda, Nemet, Ivan, Džafić, Natalija, Soldo, Barbara
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.06.2024
Subjects
Antioxidants
Cancer
Cancer cells
Chromatography
Chronic diseases
Chronic illnesses
Colon cancer
colon cancer (HCT116)
Colorectal cancer
human cervical adenocarcinoma (HeLa)
Hydrochloric acid
Istarska Bjelica
Leaves
Leccino
Nutrients
olive leaf phenolics
Oxidative stress
Pharmaceutical industry
Polyphenols
Prevention
Silicon
Solvents
Trees
Water
United States
Germany
Croatia
United States > US
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Summary:It is not yet clear how adding silicon foliar fertilisation affects olive leaf (OL) phenolics and their potential to impact different cancer cells. Thus, we conducted a field trial to study the effect of foliar Si biostimulant fertilisation on the OL phenolic content of the ‘Leccino’ (LE) and ‘Istarska Bjelica’ (IB) cultivars. The experiment compared untreated Control (C) and three distinct levels of silicon (Si1, Si2, Si3) with Si concentrations of 0.55 g/L, 1.1 g/L, and 2.2 g/L, respectively. Si3 application resulted in the highest levels of oleuropein, apigenin-7-O-glucoside, luteolin-4-O-glucoside, rutin, and tyrosol compared to the C treatment. The polyphenols showed high cytotoxic activity in three cancer cell lines tested: cervical adenocarcinoma (HeLa), colon cancer (HCT116), and osteosarcoma (U2OS). The strongest inhibition of cell growth was observed in the HCT116 cell line. All cancer cells tested were more sensitive to treatment with polyphenols isolated from plants with added Si than those without added Si. The cytotoxic activity of the extracts on the healthy cell line RPE1 was similar to that on the cancer cell line HCT116 and U2OS.
ISSN:2076-3417
2076-3417
DOI:10.3390/app14114669