Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice

• Published in: Environment, development and sustainability Vol. 23; no. 10; pp. 14958 - 14981
• Main Authors: de Oliveira, Maria Rayane Correia, de Lima Silva, Maria Gabriely, Alcântara, Isabel Sousa, Filho, Jaime Ribeiro, Tintino, Cícera Datiane de Morais Oliveira, Magalhães, Francisco Ernani Alves, Martins, Anita Oliveira Brito Pereira Bezerra, Pessoa, Renata Torres, Duarte, Antonia Eliene, da Costa, José Galberto Martins, de Lima, Sidney Gonçalo, Coutinho, Henrique Douglas Melo, Capasso, Raffaele, de Menezes, Irwin Rose Alencar
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.10.2021; Springer Nature B.V
• Subjects: Acetic acid; Acids; Analgesics; Animal models; Animals; Anti-inflammatory agents; Arachidonic acid; Bicyclogermacrene; Carrageenan; Caryophyllene; Central nervous system; Chemical composition; Dextran; Dextrans; Earth and Environmental Science; Ecology; Economic Geology; Economic Growth; Edema; Environment; Environmental Economics; Environmental Management; Essential oils; Germacrene; Granuloma; Histamine; Inflammation; Lantana montevidensis; Nervous system; Oils & fats; Pain perception; Permeability; Petroleum; Sustainable Development; Toxicity; Valencene; Antinociceptive activity; Anti-inflammatory activity; Essential oil
• ISSN: 1387-585X; 1573-2975
• DOI: 10.1007/s10668-021-01281-8

This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and 200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising antinociceptive and anti-inflammatory activities. The results of this study indicate that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting acute and chronic inflammation.