Copper-free click-a promising tool for pre-targeted PET imaging

The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [F-18]2-fluoroethylazide ([F-18]1) and optimisation of the CFC reaction with a series of cyclooctynes sho...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 48; no. 7; pp. 991 - 993
Main Authors Evans, Helen L., Slade, Rozanna L., Carroll, Laurence, Smith, Graham, Nguyen, Quang-De, Iddon, Lisa, Kamaly, Nazila, Stoeckmann, Henning, Leeper, Finian J., Aboagye, Eric O., Spivey, Alan C.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 25.01.2012
Subjects
Alkynes - chemical synthesis
Alkynes - chemistry
Animals
Azides - chemistry
Azides - pharmacokinetics
Chemistry
Chemistry, Multidisciplinary
Chlorofluorocarbons
Cyclization
Fluorine Radioisotopes - chemistry
Fluorine Radioisotopes - pharmacokinetics
Imaging
Mice
Mice, Inbred BALB C
Mice, Nude
Optimization
Physical Sciences
Positron emission
Positron-Emission Tomography - methods
Science & Technology
Tissue Distribution
Tomography
Tuning
CHEMISTRY
POSITRON-EMISSION-TOMOGRAPHY
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Summary:The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [F-18]2-fluoroethylazide ([F-18]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc16220a