Intraocular penetration of cytosine arabinoside following intravenous administration in primates

Cytosine arabinoside was administered intravenously to three monkeys. Blood, aqueous, and vitreous specimens were collected after 30 minutes, 1 hour, 2 hours, and 3 hours. Intraocular and intravenous drug concentrations were comparable at all time points, at levels likely to be effective against hum...

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Bibliographic Details
Published inJournal of ocular pharmacology Vol. 4; no. 2; p. 133
Main Authors Smiddy, W E, Graham, M L, Cheo, D L, Schachat, A P
Format Journal Article
LanguageEnglish
Published United States 1988
Subjects
Animals
Cytarabine - administration & dosage
Cytarabine - pharmacokinetics
Eye - drug effects
Eye - metabolism
Injections, Intravenous
Macaca fascicularis
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Summary:Cytosine arabinoside was administered intravenously to three monkeys. Blood, aqueous, and vitreous specimens were collected after 30 minutes, 1 hour, 2 hours, and 3 hours. Intraocular and intravenous drug concentrations were comparable at all time points, at levels likely to be effective against human tumors. This study suggests that therapeutic intraocular concentrations of cytosine arabinoside are attained following intravenous administration in primates.
ISSN:8756-3320
DOI:10.1089/jop.1988.4.133