Therapeutic Role of Fibroblast Growth Factor 21 (FGF21) in the Amelioration of Chronic Diseases

Fibroblast growth factor-21 (FGF21) is a member of the family of fibroblast growth factors (FGFs). FGF21 (synthesized by many organs) has been studied extensively for its role in the regulation of energy homeostasis. FGF21 came into the spotlight after its beneficial metabolic effects in reducing bl...

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Published inInternational journal of peptide research and therapeutics Vol. 26; no. 1; pp. 107 - 119
Main Authors Opoku, Yeboah Kwaku, Liu, Zhihang, Afrifa, Justice, Khoso, Mir Hassan, Ren, Guiping, Li, Deshan
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.03.2020
Springer Nature B.V
Subjects
Aging
Animal Anatomy
Biochemistry
Biomedical and Life Sciences
Cancer
Cardiovascular diseases
Chronic illnesses
Diabetes mellitus
Energy balance
Fibroblast growth factors
Fibroblasts
Fibrosis
Growth factors
Histology
Homeostasis
Life Sciences
Molecular Medicine
Morphology
Obesity
Organs
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Polymer Sciences
Therapeutic applications
Chronic diseases
Therapeutic
Inflammation
Fibroblast growth factor 21 (FGF21)
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Summary:Fibroblast growth factor-21 (FGF21) is a member of the family of fibroblast growth factors (FGFs). FGF21 (synthesized by many organs) has been studied extensively for its role in the regulation of energy homeostasis. FGF21 came into the spotlight after its beneficial metabolic effects in reducing blood glucose, and weight in obesity were identified. Since then, FGF21 has been extensively exploited for therapeutic purposes and clinical applications with significant achievements. Its therapeutic roles in diabetes, obesity, cardiovascular diseases, fibrosis, cancer and aging among others have been studied over the last decade with significant strides making it a promising candidate for the management of chronic diseases. Here we review the therapeutic prospects of FGF21 with emphasis on the management of chronic diseases, and breakthroughs in its shortfalls. The future of FGF21 as a therapeutic agent is auspicious and will help revolutionize the world of medicine.
ISSN:1573-3149
1573-3904
DOI:10.1007/s10989-019-09820-8