Rauvolfia tetraphylla (Devil Pepper)-Mediated Green Synthesis of Ag Nanoparticles: Applications to Anticancer, Antioxidant and Antimitotic

In the current examination, we have built up a novel, green approach for the synthesis of Ag NPs (silver nanoparticles) from Rauvolfia tetraphylla leaves extract. The synthesized Ag NPs were thoroughly characterized using different analytical techniques like Powder X-ray diffraction, Fourier transfo...

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Bibliographic Details
Published inJournal of cluster science Vol. 30; no. 6; pp. 1545 - 1564
Main Authors Vinay, S. P., Udayabhanu, Nagaraju, G., Chandrappa, C. P., Chandrasekhar, N.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.11.2019
Springer Nature B.V
Subjects
Anticancer properties
Antioxidants
Biosynthesis
Cancer
Catalysis
Chemistry
Chemistry and Materials Science
Chromosomes
Cost analysis
Electron microscopy
Flavonoids
Fourier transforms
Free radicals
Herbal medicine
Hypertension
Infrared analysis
Infrared spectroscopy
Inorganic Chemistry
Investigations
Mental disorders
Microorganisms
Nanochemistry
Nanomaterials
Nanoparticles
Nanotechnology
Original Paper
Physical Chemistry
Reducing agents
Scavenging
Silver
Synthesis
Tropical diseases
X ray powder diffraction
Ag nanoparticles
Antioxidant
Anticancer
Antimitotic
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Summary:In the current examination, we have built up a novel, green approach for the synthesis of Ag NPs (silver nanoparticles) from Rauvolfia tetraphylla leaves extract. The synthesized Ag NPs were thoroughly characterized using different analytical techniques like Powder X-ray diffraction, Fourier transform infrared spectroscopy, UV–visible spectroscopy, scanning electron microscopy and transmission electron microscope analysis. It is confirmed as a cubic phased silver nanoparticle with an average particle size of around 40 nm with a spherical shape. Further, the characterized material was examined for antioxidant activity and it has shown the IC 50 (inhibitory concentration 50%) value of 82.13 µg/mL against the scavenging of DPPH free radical. The cytogenetic effect of silver nanoparticles was tested on the root cells of Allium cepa, from this examination we have noted the antimitotic activity and precise chromosomal aberrations such as chromosome-breaks, chromosome-stickiness, laggard chromosome, clumped chromosome etc. By discharging Ag + ions and producing ROS, silver nanoparticle exhibits great anticancer activity. Therefore, this paperwork effectively shows the synthesis of Ag nanoparticles by simple eco-friendly green way utilizing Rauvolfia tetraphylla leaves to extract as a green reducing agent as well as stabilizing/capping agent for the synthesis of Ag NPs. Graphic abstract
ISSN:1040-7278
1572-8862
DOI:10.1007/s10876-019-01598-5