Nuclear membrane: A key potential therapeutic target for lipid metabolism

Lipid homeostasis plays a pivotal role in cellular growth, necessitating the engagement of numerous lipid metabolism genes and the cohesive functioning of organelles. While the nucleus is traditionally recognized for its genetic roles, emerging evidence highlights its significant contribution to lip...

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Bibliographic Details
Published inProgress in biophysics and molecular biology Vol. 194; pp. 10 - 15
Main Authors Zeng, Min, Chen, Longgui, Wang, YaZhu
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2024
Subjects
Animals
Humans
Lamins
Lipid Metabolism
Molecular Targeted Therapy
Nuclear Envelope - metabolism
Nucleus membrane
Nucleus membrane
Lamins
Lipid metabolism
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Summary:Lipid homeostasis plays a pivotal role in cellular growth, necessitating the engagement of numerous lipid metabolism genes and the cohesive functioning of organelles. While the nucleus is traditionally recognized for its genetic roles, emerging evidence highlights its significant contribution to lipid homeostasis maintenance. Certain nuclear membrane proteins or associated proteins have the capacity to directly catalyze lipid synthesis or modification processes. Mutations in the genes encoding these proteins can lead to disrupted lipid metabolism, contributing to a spectrum of metabolic disorders. This article provides a comprehensive reviews of the investigations exploring the interplay between nuclear membrane proteins and lipid metabolism. Additionally, it delves into the heterogeneity of the nuclear membrane, positioning it as a novel therapeutic target for managing metabolic disorders and mitigating adverse drug reactions.
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ISSN:0079-6107
1873-1732
1873-1732
DOI:10.1016/j.pbiomolbio.2024.10.002