Efficacy and Safety Assessment of Topical Omega Fatty Acid Product in Experimental Model of Irritant Contact Dermatitis: Randomized Controlled Trial

Contact dermatitis is a common inflammatory skin disease that often requires prescription therapy and is associated with adverse reactions. Omega fatty acids have been recognized for their anti-inflammatory effect and could serve as a safer option in contact dermatitis treatment. Therefore, the aim...

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Published inApplied sciences Vol. 14; no. 15; p. 6423
Main Authors Ivic, Magdalena, Slugan, Ana, Leskur, Dario, Rusic, Doris, Seselja Perisin, Ana, Modun, Darko, Durdov, Toni, Bozic, Josko, Vukovic, Dubravka, Bukic, Josipa
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2024
Subjects
Clinical medicine
Contact dermatitis
Cytokines
Dermatitis
eczema
Erythema
Fatty acids
Hydration
irritant contact dermatitis
omega acids
Psoriasis
Rilastil
Side effects
Skin
skin barrier
Skin diseases
Skin lesions
Germany
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Summary:Contact dermatitis is a common inflammatory skin disease that often requires prescription therapy and is associated with adverse reactions. Omega fatty acids have been recognized for their anti-inflammatory effect and could serve as a safer option in contact dermatitis treatment. Therefore, the aim of this randomized controlled study, conducted at the University of Split School of Medicine, was to evaluate the efficacy and safety of omega fatty acids containing topical products in an experimental model of irritant contact dermatitis. This study was registered with ClinicalTrials (NCT06189144) and is closed. The primary outcomes were levels of transepidermal water loss, skin hydration, and skin erythema, all measured using an MPA6 device in 25 healthy participants. A significant difference was observed between the hydration values of the intervention (45.7 ± 12.4) and control groups (31.6 ± 12.3) (p < 0.05) on final measurements (day 10). Moreover, higher erythema levels were observed in participants who were smokers, compared to non-smokers. No adverse drug reactions were observed during the study period. In conclusion, omega fatty acids topical product use shows promise in the treatment of irritant contact dermatitis, and further studies are needed to evaluate efficacy in a larger sample of patients.
ISSN:2076-3417
2076-3417
DOI:10.3390/app14156423