Temozolomide associated to gold nanoparticles promoted a synergic effect and apoptosis when exposed to melanoma cells

Temozolomide (TMZ) is prescribed primarily because of its known ability to cross the blood-brain barrier, being a potentially chemotherapic drug for cancer treatment. However, it has dose-limiting hemotoxicity and rapid hydrolysis, which limits its anti-tumor efficacy. On the other hand, recent stud...

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Bibliographic Details
Published inJournal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology Vol. 24; no. 7
Main Authors dos Santos Pedroso-Fidelis, Giulia, de Melo, Maria Eduarda, Possato, Jonathann Corrêa, Fernandes, Bruna Barros, De Pieri, Ellen, Cercena, Rodrigo, Dal-Bó, Alexandre Gonçalves, Feuser, Paulo Emilio, Machado-de-Ávila, Ricardo Andrez
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.07.2022
Springer Nature B.V
Subjects
Anticancer properties
Apoptosis
Biocompatibility
Blood-brain barrier
Cell death
Characterization and Evaluation of Materials
Chemistry and Materials Science
Chemotherapy
Cytotoxicity
Electrostatic properties
Erythrocytes
Gold
Inorganic Chemistry
Lasers
Materials Science
Melanoma
Nanoparticles
Nanotechnology
Optical Devices
Optics
Photonics
Physical Chemistry
Physicochemical properties
Research Paper
Synergism
Temozolomide
Tumor cells
Hemolysis
Temozolomide
Fibroblast
Gold Nanoparticles
Melanoma
Cancer
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Summary:Temozolomide (TMZ) is prescribed primarily because of its known ability to cross the blood-brain barrier, being a potentially chemotherapic drug for cancer treatment. However, it has dose-limiting hemotoxicity and rapid hydrolysis, which limits its anti-tumor efficacy. On the other hand, recent studies have shown that gold nanoparticles (GNPs) with their biocompatibility and cytotoxic potential in tumor cells can be combined with chemotherapy leading to an improvement in the existing treatment. Thus, this work aimed to evaluate the cytotoxic effects of TMZ associated with GNPs (T-GNPs) on B16F10 cells. Different GNPs were successfully synthetized, and the results showed that there was an electrostatic interaction between TMZ and GNPs, not changing their physicochemical properties. TMZ associated with GNPs exposed on B16F10 cells presented a cytotoxic effect even more pronounced than free TMZ. In addition, different T-GNPs did not induced cytotoxic effect on non-tumor cells (NIH3T3 and red blood cells). A synergism between TMZ and GNPs was observed, inducing B16F10 cell death by apoptosis.
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-022-05524-1