Aripiprazole-induced seizure in a 3-year-old child: a case report and literature review

Aripiprazole is an atypical antipsychotic medication that is a partial dopamine D(2) and serotonin 5-hydroxytryptamine (1A) receptor agonist and 5-hydroxytryptamine (2A) receptor antagonist. It has a safer profile compared to other antipsychotic medications with regard to its effect on weight, gluco...

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Bibliographic Details
Published inClinical neuropharmacology Vol. 36; no. 1; p. 29
Main Authors Thabet, Farouq I, Sweis, Rochelle T, Joseph, Suja A
Format Journal Article
LanguageEnglish
Published United States 01.01.2013
Subjects
Antipsychotic Agents - adverse effects
Aripiprazole
Child, Preschool
Female
Humans
Incidental Findings
Piperazines - adverse effects
Quinolones - adverse effects
Seizures - chemically induced
Seizures - diagnosis
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Summary:Aripiprazole is an atypical antipsychotic medication that is a partial dopamine D(2) and serotonin 5-hydroxytryptamine (1A) receptor agonist and 5-hydroxytryptamine (2A) receptor antagonist. It has a safer profile compared to other antipsychotic medications with regard to its effect on weight, glucose tolerance, prolactin level, and cardiac conduction. The common neurological adverse effects include headache, agitation, insomnia, sleepiness, and extrapyramidal symptoms. Seizures have not been reported in the pediatric population and only twice in adult patients. Here, we report a case of a healthy 3-year-old child who experienced prolonged lethargy, dystonia, and 2 witnessed seizures after incidental ingestion of 30 mg of aripiprazole. To our knowledge, this is the first reported case of aripiprazole-induced seizures in a child.
ISSN:1537-162X
DOI:10.1097/WNF.0b013e3182767efb