A novel synthetic strategy for monosubstituted cyclodextrin derivatives

• Published in: Chemical communications (Cambridge, England) Vol. 48; no. 32; pp. 3875 - 3877
• Main Authors: Di Fabio, Giovanni, Malgieri, Gaetano, Isernia, Carla, D'Onofrio, Jennifer, Gaglione, Maria, Messere, Anna, Zarrelli, Armando, De Napoli, Lorenzo
• Format: Journal Article
• Language: English
• Published: England 21.04.2012
• Subjects: Cadmium sulfides; Conjugates; Covalence; Cyclodextrins; Cyclodextrins - chemical synthesis; Cyclodextrins - chemistry; Derivatives; Labels; Magnetic Resonance Spectroscopy; Organophosphorus Compounds - chemistry; Solid phases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Strategy

A first solid phase approach to obtain monosubstituted CD conjugates to different labels has been developed. A new solid support has been designed to get a variety of C-6 monofunctionalized CDs (α, β, MeβCD and HPβCD) covalently linked through a phosphodiester bridge to different labels, in highly p...