A novel synthetic strategy for monosubstituted cyclodextrin derivatives

A first solid phase approach to obtain monosubstituted CD conjugates to different labels has been developed. A new solid support has been designed to get a variety of C-6 monofunctionalized CDs (α, β, MeβCD and HPβCD) covalently linked through a phosphodiester bridge to different labels, in highly p...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 48; no. 32; pp. 3875 - 3877
Main Authors Di Fabio, Giovanni, Malgieri, Gaetano, Isernia, Carla, D'Onofrio, Jennifer, Gaglione, Maria, Messere, Anna, Zarrelli, Armando, De Napoli, Lorenzo
Format Journal Article
LanguageEnglish
Published England 21.04.2012
Subjects
Cadmium sulfides
Conjugates
Covalence
Cyclodextrins
Cyclodextrins - chemical synthesis
Cyclodextrins - chemistry
Derivatives
Labels
Magnetic Resonance Spectroscopy
Organophosphorus Compounds - chemistry
Solid phases
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Strategy
Online AccessGet full text

Cover

More Information
Summary:A first solid phase approach to obtain monosubstituted CD conjugates to different labels has been developed. A new solid support has been designed to get a variety of C-6 monofunctionalized CDs (α, β, MeβCD and HPβCD) covalently linked through a phosphodiester bridge to different labels, in highly pure form and under very mild detachment conditions.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc30550j