From straight to curved: A historical perspective of DNA shape

• Published in: Progress in biophysics and molecular biology Vol. 193; pp. 46 - 54
• Main Authors: Benvenuti, Jean Lucas, Casa, Pedro Lenz, Pessi de Abreu, Fernanda, Martinez, Gustavo Sganzerla, de Avila e Silva, Scheila
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2024
• Subjects: Bacterial promoters; Bioinformatic; DNA - genetics; DNA curvature; DNA physico-chemical properties; Genome annotation; Humans; Nucleic Acid Conformation; Promoter prediction; Promoter Regions, Genetic; DNA physico-chemical properties; Bioinformatic; Promoter prediction; Genome annotation; DNA curvature; Bacterial promoters
• ISSN: 0079-6107; 1873-1732; 1873-1732
• DOI: 10.1016/j.pbiomolbio.2024.09.002

DNA is the macromolecule responsible for storing the genetic information of a cell and it has intrinsic properties such as deformability, stability and curvature. DNA Curvature plays an important role in gene transcription and, consequently, in the subsequent production of proteins, a fundamental pr...