From straight to curved: A historical perspective of DNA shape

DNA is the macromolecule responsible for storing the genetic information of a cell and it has intrinsic properties such as deformability, stability and curvature. DNA Curvature plays an important role in gene transcription and, consequently, in the subsequent production of proteins, a fundamental pr...

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Published inProgress in biophysics and molecular biology Vol. 193; pp. 46 - 54
Main Authors Benvenuti, Jean Lucas, Casa, Pedro Lenz, Pessi de Abreu, Fernanda, Martinez, Gustavo Sganzerla, de Avila e Silva, Scheila
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.2024
Subjects
Bacterial promoters
Bioinformatic
DNA - genetics
DNA curvature
DNA physico-chemical properties
Genome annotation
Humans
Nucleic Acid Conformation
Promoter prediction
Promoter Regions, Genetic
DNA physico-chemical properties
Bioinformatic
Promoter prediction
Genome annotation
DNA curvature
Bacterial promoters
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Summary:DNA is the macromolecule responsible for storing the genetic information of a cell and it has intrinsic properties such as deformability, stability and curvature. DNA Curvature plays an important role in gene transcription and, consequently, in the subsequent production of proteins, a fundamental process of cells. With recent advances in bioinformatics and theoretical biology, it became possible to analyze and understand the involvement of DNA Curvature as a discriminatory characteristic of gene-promoting regions. These regions act as sites where RNAp (ribonucleic acid-polymerase) binds to initiate transcription. This review aims to describe the formation of Curvature, as well as highlight its importance in predicting promoters. Furthermore, this article provides the potential of DNA Curvature as a distinguishing feature for promoter prediction tools, as well as outlining the calculation procedures that have been described by other researchers. This work may support further studies directed towards the enhancement of promoter prediction software.
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ISSN:0079-6107
1873-1732
1873-1732
DOI:10.1016/j.pbiomolbio.2024.09.002