Donor leukocyte infusion for treatment of graft rejection post partially mismatched related donor bone marrow transplant

Graft rejection following bone marrow transplantation is more common in patients who receive their grafts from alternative donors and whose marrow is T cell depleted. Rejection in these patients is mediated by persistent host cells that interfere with successful establishment of donor-derived hemato...

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Bibliographic Details
Published inBone marrow transplantation (Basingstoke) Vol. 22; no. 1; pp. 111 - 113
Main Authors GODDER, K. T, ABHYANKAR, S. H, LAMB, L. S, BEST, R. G, GEIER, S. S, PATI, A. R, GEE, A. P, HENSLEE-DOWNEY, P. J
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 01.07.1998
Subjects
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Graft Rejection - therapy
Histocompatibility
Humans
Leukemia, Myeloid, Accelerated Phase - therapy
Leukocyte Transfusion
Male
Medical sciences
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation, Homologous
Chromosomal aberration
Blood product
HLA-System
Transfusion
Leukocyte
Major histocompatibility system
Male
Myeloproliferative syndrome
Partial
Chronic myelocytic leukemia
Genetics
Adult
Chromosome translocation
Human
Related donor
Malignant hemopathy
Philadelphia chromosome
Case study
Rejection
Chronic
Treatment
Cytogenetics
Abnormal chromosome
Chimerism
Histocompatibility
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Summary:Graft rejection following bone marrow transplantation is more common in patients who receive their grafts from alternative donors and whose marrow is T cell depleted. Rejection in these patients is mediated by persistent host cells that interfere with successful establishment of donor-derived hematopoietic recovery. We describe a patient with chronic myelogenous leukemia in accelerated phase who rejected a T cell-depleted bone marrow graft, 2 months following partially mismatched related donor bone marrow transplant. Unmanipulated peripheral blood donor leukocyte infusion, without additional chemotherapy or immunosuppressive therapy resulted in complete hematopoietic recovery. Cytogenetics and RFLP demonstrated hematopoietic donor chimerism. The patient did not develop graft-versus-host disease.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ISSN:0268-3369
1476-5365
DOI:10.1038/sj.bmt.1701278