Novel theranostic nanoagent based on CuMo2S3-PEG-Gd for MRI-guided photothermal/photodynamic/chemodynamic therapy

Cancer is a severe disease, which have troubled human being for a long time. The development of nanotechnology has provided a new way for cancer treatment. It is a promising strategy to integrate imaging and therapeutic functions into one single nanoplatform to achieve efficient combination of diagn...

Full description

Saved in:
Bibliographic Details
Published inRare metals Vol. 41; no. 1; pp. 45 - 55
Main Authors Zheng, Nan-Nan, Kong, Wen-Yan, Huang, Zhi, Liu, Xi-Jian, Liang, Shan-Hui, Deng, Guo-Ying, Zhao, Lin-Jing, Lu, Jie
Format Journal Article
LanguageEnglish
Published Beijing Nonferrous Metals Society of China 2022
Springer Nature B.V
Subjects
Biocompatibility
Biomaterials
Cancer
Chemistry and Materials Science
Energy
Gadolinium
Magnetic resonance imaging
Materials Engineering
Materials Science
Medical imaging
Metallic Materials
Nanocomposites
Nanoscale Science and Technology
Original Article
Photodynamic therapy
Photothermal conversion
Physical Chemistry
Synergistic effect
Tumors
S
Photothermal therapy (PTT)
CuMo
Magnetic resonance imaging (MRI)
PEG-Gd NCs
Chemodynamic therapy (CDT)
Combined therapy
Online AccessGet full text

Cover

More Information
Summary:Cancer is a severe disease, which have troubled human being for a long time. The development of nanotechnology has provided a new way for cancer treatment. It is a promising strategy to integrate imaging and therapeutic functions into one single nanoplatform to achieve efficient combination of diagnosis and treatment. Herein, we exploited novel CuMo 2 S 3 -PEG-Gd nanocomposites (NCs) for magnetic resonance imaging (MRI), guiding the photothermal therapy (PTT)/photodynamic therapy (PDT)/chemodynamic therapy (CDT). The experimental results showed that CuMo 2 S 3 -PEG-Gd NCs have a high photothermal conversion efficiency (40.6%), excellent biocompatibility and good biosecurity. The CuMo 2 S 3 -PEG-Gd NCs exhibited a clear MRI performance for tumor due to connecting Gd, which can guide in vivo therapy to improve the therapeutic effect. Moreover, both in vitro and in vivo therapeutic results of CuMo 2 S 3 -PEG-Gd NCs exhibited that the PTT/PDT/CDT achieved a remarkably synergistic effect, which could efficiently inhibit the tumor growth. Thus, CuMo 2 S 3 -PEG-Gd NCs, which integrated imaging with multiple therapies, have a good potential as theranostic agent for tumor. Graphical abstract
ISSN:1001-0521
1867-7185
DOI:10.1007/s12598-021-01793-2