Ovarian Reserve and Pelvic Ultrasound Assessment in Familial Mediterranean Fever

• Published in: Curēus (Palo Alto, CA) Vol. 14; no. 8; p. e28027
• Main Authors: Okuyucu, Muhammed, Ozdemir, Ayse Zehra, Yalcin Kehribar, Demet, Ozgen, Metin
• Format: Journal Article
• Language: English
• Published: Palo Alto Cureus Inc 15.08.2022; Cureus
• Subjects: Abortion; Amyloidosis; Fertility; Fever; Gynecology; Hormones; Infertility; Internal Medicine; Mutation; Obstetrics/Gynecology; Ovaries; Peritonitis; Pregnancy; Rheumatology; Ultrasonic imaging; Variables
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.28027

IntroductionFamilial Mediterranean fever (FMF) is an inflammatory rheumatic disease that affects people in their reproductive period. The aim of this study was to investigate the number of gravida, ovarian reserve, and ovarian doppler characteristics in FMF patients.MethodsThe study design is cross-sectional. Between November 1, 2018, and October 31, 2019, 40 FMF patients, and 40 age-matched volunteers were included in the study. Early follicular phase follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2), progesterone, and anti-Mullerian hormone (AMH) levels, as well as ovarian volume, antral follicle count (AFC), ovarian stromal artery doppler findings, and pelvic pathologies, were evaluated.ResultsThe number of gravida, and the AFC was significantly higher in the control group (16.00 ± 5.22) compared to the patients with FMF (13.00 ± 4.09) (p = 0.026). LH values were significantly higher in the FMF group. Thirteen patients (32.5%) received anakinra and colchicine, and 27 patients (67.5%) received only colchicine. There was no significant difference between the patients receiving anakinra, and the patients receiving colchicine in terms of AMH, FSH, AFC, and E2 values.ConclusionFMF patients were found to have low gravida and AFC, and a significant portion was observed to have pelvic fluid and hydrosalpinx. In conclusion, the presence of pelvic fluid, hydrosalpinx, and low AFC persist in FMF patients despite colchicine and/or anti-interleukin-1 treatments. The low gravida may be related to these pathologies detected in patients with FMF.