From Single- to Multi-organ-on-a-Chip System for Studying Metabolic Diseases

• Published in: Biochip journal Vol. 17; no. 2; pp. 133 - 146
• Main Authors: Jang, Minjeong, Kim, Hong Nam
• Format: Journal Article
• Language: English
• Published: Seoul The Korean BioChip Society (KBCS) 01.06.2023; Springer Nature B.V
• Subjects: Biochips; Biomedical Engineering and Bioengineering; Biotechnology; Body fat; Chemistry; Chemistry and Materials Science; Crosstalk; Diabetes; Energy; Fatty acids; Gastrointestinal surgery; Global health; Glucose; Homeostasis; Hormones; Hyperglycemia; Insulin resistance; Lipids; Metabolic disorders; Metabolic syndrome; Metabolites; Musculoskeletal system; Neurodegeneration; Neurosciences; New technology; Obesity; Oxidation; Pancreas; Pathogenesis; Peptides; Physiology; Proteins; Public health; Review Article; Metabolic disease; Obesity; Organ-on-a-chip; Non-alcoholic fatty liver disease; Diabetes mellitus
• ISSN: 1976-0280; 2092-7843
• DOI: 10.1007/s13206-023-00098-z

Metabolic diseases have been a major public health issue and a clinical challenge worldwide. Dysfunction of metabolic homeostasis is linked to the onset of various diseases because the various metabolizing organs synchronously interact to maintain metabolic homeostasis. Therefore, understanding inter-organ communication is important to develop more accurate drug testing and discovery for the treatment of metabolic diseases. The physiologically relevant organ-on-a-chip system is an emerging technology to study metabolic dynamics by providing an organ-level platform. This review summarizes the single- and multi-organ chip systems to study metabolic diseases and their dynamics, focusing on their inter-organ crosstalk.