Fabrication of Endothelial Cell-Lining Polyurethane/Polycaprolactone Tubular Scaffold Coated with Conjugated Linoleic Acid for Small-Diameter Vascular Graft

Artificial vascular transplantation is one of the potential state-of-the-art therapies for cardiovascular diseases, which are known as a leading cause of death worldwide. With the development of vascular tissue engineering, researchers have succeeded in creating large-caliber vascular structures. Ho...

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Published inFibers and polymers Vol. 24; no. 2; pp. 423 - 432
Main Authors Vu, Binh Thanh, Nguyen, Phuc Dang-Ngoc, Tran, Nam Minh-Phuong, Tang, Tuan-Ngan, Do, Thai Minh, Vo, Toi Van, Nguyen, Hiep Thi
Format Journal Article
LanguageEnglish
Published Seoul The Korean Fiber Society 01.02.2023
Springer Nature B.V
Subjects
Blood vessels
Chemistry
Chemistry and Materials Science
Endothelial cells
Grafting
Nanofibers
Occlusion
Physical properties
Polycaprolactone
Polymer Sciences
Polyurethane resins
Regular Article
Scaffolds
Tissue engineering
Transplantation
Vascular tissue
Electrospinning
Conjugated linoleic acid
Polycaprolactone
Artificial vascular graft
Polyurethane
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Summary:Artificial vascular transplantation is one of the potential state-of-the-art therapies for cardiovascular diseases, which are known as a leading cause of death worldwide. With the development of vascular tissue engineering, researchers have succeeded in creating large-caliber vascular structures. However, the challenges of fabricating artificial blood vessels less than 6 mm in diameter remain unsolved. In this study, we fabricated tubular structures of this size from blended polyurethane/polycaprolactone nanofibers coated with anti-thrombogenic agents and lined with endothelial cells. The polymeric structure from those two cytocompatible polymers demonstrated suitable physical properties as a vascular graft. Further investigation on cell-material interaction with bovine artery endothelial cells established that the conjugated linoleic acid-grafted scaffold supported monolayer endothelial proliferation while limiting platelet adhesion. This approach could pave a way for developing a promising therapeutic method of artificial vascular transplantation that effectively overcomes occlusion.
ISSN:1229-9197
1875-0052
DOI:10.1007/s12221-023-00096-w