Feasibility of Transanal Local Excision Following Chemoradiation for Lower Rectal Cancer

• Published in: Anticancer research Vol. 37; no. 10; p. 5617
• Main Authors: Tokunaga, Takuya, Nishi, Masaaki, Higashijima, Jun, Yoshikawa, Kozo, Kashihara, Hideya, Takasu, Chie, Ishikawa, Daichi, Bando, Yoshimi, Shimada, Mitsuo
• Format: Journal Article
• Language: English
• Published: Greece 01.10.2017
• Subjects: Aged; Chemoradiotherapy, Adjuvant - adverse effects; Chemoradiotherapy, Adjuvant - mortality; Colonoscopy; Digestive System Surgical Procedures - adverse effects; Digestive System Surgical Procedures - methods; Digestive System Surgical Procedures - mortality; Disease-Free Survival; Feasibility Studies; Female; Humans; Kaplan-Meier Estimate; Length of Stay; Male; Middle Aged; Neoadjuvant Therapy - adverse effects; Neoadjuvant Therapy - mortality; Neoplasm Staging; Rectal Neoplasms - mortality; Rectal Neoplasms - pathology; Rectal Neoplasms - therapy; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome; disease-free survival; local excision; overall survival; low anterior resection; clinical complete response; Chemoradiation therapy; total mesorectal excision
• ISSN: 1791-7530; 1791-7530
• DOI: 10.21873/anticanres.11996

The aim of this study was to evaluate the clinical outcome of transanal local excision for cT1/cT2 lower rectal cancer following pre-operative chemoradiation therapy (CRT). Eleven patients who underwent pre-operative CRT for cT1/cT2 lower rectal cancer were retrospectively enrolled in this study. Surgical outcomes were compared between the group that underwent trasanal local excision (TLE) (n=6) and that which underwent total mesorectal excision (TME) (n=5). Regarding surgical outcomes, there were significant differences between the two groups in operative time, rate of anal preservation and post-operative hospital stay. There were no differences between the two groups in the disease-free or overall survival rates. The TLE following CRT had acceptable surgical outcomes. Surgeons should consider TLE following CRT for cT1/cT2 lower rectal cancer as a treatment option in selected patients.