A Probabilistic Patch-Based Label Fusion Model for Multi-Atlas Segmentation With Registration Refinement: Application to Cardiac MR Images

• Published in: IEEE transactions on medical imaging Vol. 32; no. 7; pp. 1302 - 1315
• Main Authors: Wenjia Bai, Wenzhe Shi, O'Regan, D. P., Tong Tong, Haiyan Wang, Jamil-Copley, S., Peters, N. S., Rueckert, D.
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.07.2013
• Subjects: Accuracy; Algorithms; Bayes methods; Bayes Theorem; Gaussian distribution; Heart - anatomy & histology; Heart Ventricles - anatomy & histology; Humans; Image Processing, Computer-Assisted - methods; Image registration; Image segmentation; Magnetic Resonance Imaging - methods; multi-atlas segmentation; patch-based segmentation; Probabilistic logic; Vectors
• ISSN: 0278-0062; 1558-254X; 1558-254X
• DOI: 10.1109/TMI.2013.2256922

The evaluation of ventricular function is important for the diagnosis of cardiovascular diseases. It typically involves measurement of the left ventricular (LV) mass and LV cavity volume. Manual delineation of the myocardial contours is time-consuming and dependent on the subjective experience of the expert observer. In this paper, a multi-atlas method is proposed for cardiac magnetic resonance (MR) image segmentation. The proposed method is novel in two aspects. First, it formulates a patch-based label fusion model in a Bayesian framework. Second, it improves image registration accuracy by utilizing label information, which leads to improvement of segmentation accuracy. The proposed method was evaluated on a cardiac MR image set of 28 subjects. The average Dice overlap metric of our segmentation is 0.92 for the LV cavity, 0.89 for the right ventricular cavity and 0.82 for the myocardium. The results show that the proposed method is able to provide accurate information for clinical diagnosis.