Aptamer-modified paper-based analytical devices for the detection of food hazards: Emerging applications and future perspective

• Published in: Biotechnology advances Vol. 73; p. 108368
• Main Authors: Qin, Mingwei, Khan, Imran Mahmood, Ding, Ning, Qi, Shuo, Dong, Xiaoze, Zhang, Yin, Wang, Zhouping
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.07.2024
• Subjects: Aptamer-modified paper-based analytical devices; Aptamers, Nucleotide - chemistry; Biosensing Techniques - instrumentation; Biosensing Techniques - methods; Food analysis; Food Analysis - instrumentation; Food Analysis - methods; Food Contamination - analysis; Food hazards; Food Safety - methods; Humans; Point-of-care testing; Point-of-care testing; Food analysis; Aptamer-modified paper-based analytical devices; Food hazards
• ISSN: 0734-9750; 1873-1899; 1873-1899
• DOI: 10.1016/j.biotechadv.2024.108368

Food analysis plays a critical role in assessing human health risks and monitoring food quality and safety. Currently, there is a pressing need for a reliable, portable, and quick recognition element for point-of-care testing (POCT) to better serve the demands of on-site food analysis. Aptamer-modified paper-based analytical devices (Apt-PADs) have excellent characteristics of high portability, high sensitivity, high specificity, and on-site detection, which have been widely used and concerned in the field of food safety. The article reviews the basic components and working principles of Apt-PADs, and introduces their representative applications detecting food hazards. Finally, the advantages, challenges, and future directions of Apt-PADs-based sensing performance are discussed, to provide new directions and insights for researchers to select appropriate Apt-PADs according to specific applications. •The special composition and structure of Apt-PADs are systematically described.•In-depth description of the sensing applications of Apt-PADs and the research progress in recent years.•Intervention strategies of aptamers and paper bases to obtain high sensitivity of Apt-PADs.•Specific outlook on the future direction of Apt-PADs improvements.