The fate of spikes in self-limited epilepsy with centrotemporal spikes: Are clinical and baseline EEG features effective?

• Published in: Epilepsy research Vol. 193; p. 107165
• Main Authors: Günay, Çağatay, Sarikaya Uzan, Gamze, Özsoy, Özlem, Hiz Kurul, Semra, Yiş, Uluç
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2023
• Subjects: Electroencephalogram (EEG); Electroencephalography; Epilepsy, Rolandic - drug therapy; Humans; Levetiracetam; Retrospective Studies; Rolandic epilepsy; Seizures - drug therapy; Self-limited epilepsy with centrotemporal spikes (SeLECTS); Spike rate; Spike wave index; Valproate; Valproic Acid; Rolandic epilepsy; Spike rate; Self-limited epilepsy with centrotemporal spikes (SeLECTS); Electroencephalogram (EEG); Spike wave index; Valproate
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2023.107165

The aim of this study is to evaluate the effects of clinical and electroencephalographic features on spike reduction with a focus on the first EEG characteristics in self-limited epilepsy with centrotemporal spikes (SeLECTS). This retrospective study was conducted on SeLECTS patients of with at least five years follow-up and at least two EEG recordings in which spike wave indexes (SWI) were calculated. 136 patients were enrolled. Median SWI in the first and last EEGs were 39% (7.6–89%) and 0 (0–112%). Gender, seizure onset age, psychiatric diseases, seizure characteristics (semiology, duration, and relationship to sleep), last EEG time, and spike lateralization in the first EEG did not have a statistically significant effect on the SWI change. Multinomial logistic regression analysis revealed that presence of phase reversal, interhemispheric generalization, and SWI percentage had a significant effect on spike reduction. The frequency of seizures was also significantly decreased in patients with a greater decrease in SWI. Both valproate and levetiracetam were statistically superior in suppressing SWI, with no significant difference between them. Interhemispheric generalization and phase reversal in the first EEG in SeLECTS had negative effects on the spike reduction. The most effective ASMs in reducing spikes were valproate and levetiracetam. •Phase reversal in the first EEG recordings had a negative effect on spike reduction.•Spike reduction was negatively impacted by interhemispheric generalization in the first EEG.•Decreases in spike waves and seizure frequency were correlated.•Electroencephalographic improvement was more common in patients receiving monotherapy.•Valproate and levetiracetam were the most effective drugs in spike reduction.