Use of a calcium phosphate matrix as a temporary cast for bony defect repair: a pilot study

• Published in: Journal of materials science Vol. 38; no. 9; pp. 1875 - 1883
• Main Authors: ROELS, A, CORNELISSEN, M, DE MAEYER, E. A. P, THIERENS, H, VERBEECK, R. M. H, DERMAUT, L. R
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.05.2003; Springer Nature B.V
• Subjects: Biocompatibility; Biodegradability; Biological and medical sciences; Bone cements; Calcium phosphates; Crystal defects; Dogs; Formulations; Materials science; Medical sciences; Repair; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Calcium Phosphates; Biocompatibility; Biomaterial; Bone remodeling; Cement
• ISSN: 0022-2461; 1573-4803
• DOI: 10.1023/A:1023536026502

The bony repair effect of different Calcium Phosphate Bone Cements was tested in a dog model. Seven different formulations were synthesized and tested on their biocompatibility, osseoconduction and biodegradability. Three dogs were used in this pilot study, in each dog 4 cranial, circular defects were made with a critical size diameter of 12 mm. Autologous bone was used as a control. The dogs were sacrificed after 6 months. Mineral phase analysis showed a reaction of the cements to form a more or less crystalline calciumhydroxyapatite. Histologic evaluation revealed that the presence of the cements stimulated the formation of a thin bone layer on the cranial and caudal side of each defect. The cements did not evoke an inflammatory reaction. Two formulations showed extensive bone formation.