Characterization and evaluation of cytotoxic effect, antioxidant and antimicrobial activities of zinc oxide nanoparticles derived from Justicia adhatoda

• Published in: Applied nanoscience Vol. 13; no. 6; pp. 3993 - 4004
• Main Authors: Rajeshkumar, S., Santhoshkumar, J., Kumar, P. Senthil, Saravanan, A., Tharani, M.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2023; Springer Nature B.V
• Subjects: Antiinfectives and antibacterials; Chemistry and Materials Science; E coli; Free radicals; Fungicides; Materials Science; Membrane Biology; Nanochemistry; Nanoparticles; Nanotechnology; Nanotechnology and Microengineering; Original Article; Scavenging; Toxicity; Zinc oxide; Antimicrobial; Zinc oxide nanoparticle; Cytotoxicity; Antifungal; MCF-7 cell line
• ISSN: 2190-5509; 2190-5517
• DOI: 10.1007/s13204-022-02670-9

The current study describes a green synthesis method for preparing zinc oxide nanoparticles (ZnO-NPs) using Justicia adhatoda to investigate the different pathogen and toxic assays. Synthesized nanoparticles are hexagonal and 40 nm in size. The antifungal activity of ZnO-NPs was analyzed against three strains: Aspergillus fumigatus , Aspergillus flavus, and Aspergillus niger . The antimicrobial activity of ZnO-NPs as tested against Bacillus , Escherichia coli, and Staphylococcus aureus . The ZnO-NPs produced exhibited significant free radical scavenging effects of 200 µg/mL-73.12%. ZnO-NPs were evaluated against MCF-7 human breast cancer cells at an LD50 concentration of 50 µg/mL. The results showed that biosynthesized ZnO-NPs have efficient inhibitory activity against fungal and bacterial strains and cytotoxicity against human MCF-7 breast cancer cell lines.