Anti-Obesity and Antidiabetic Effects of Fig (Ficus carica L.) Fermented Extract Using Lactobacillus plantarum BT-LP-01

This study aimed to assess the effect of fermented fig (Ficus carica L., FF) on obesity and diabetes in a mouse model. FF was cultured with the lactic acid bacterium Lactobacillus plantarum BT-LP-01 and isolated from fig peels. The antioxidant results demonstrated that FF exhibited DPPH and ABTS rad...

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Published inApplied sciences Vol. 14; no. 15; p. 6412
Main Authors Choi, Hwal, Choi, Jihye, Jang, Yuseong, Lee, Young-Min, Kang, Myoung-Hak, Kwon, Hyuck-Se, Kim, Sokho, Kwon, Jungkee
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2024
Subjects
Analysis
anti-obesity
antidiabetic
Antidiabetics
Antioxidants
Blood sugar
Body fat
Body weight
Cancer
Cholesterol
Content analysis
Diabetes
Diet
Fatty acids
Ficus carica
Flavonoids
hyperglycemia
Isoflavones
lipid metabolism
Liraglutide
Liver
Lorcaserin
Metabolism
Microorganisms
Obesity
Phenols
Physiological aspects
Probiotics
R&D
Research & development
Type 2 diabetes
South Korea
Japan
Missouri
St Louis Missouri
United States > US
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Summary:This study aimed to assess the effect of fermented fig (Ficus carica L., FF) on obesity and diabetes in a mouse model. FF was cultured with the lactic acid bacterium Lactobacillus plantarum BT-LP-01 and isolated from fig peels. The antioxidant results demonstrated that FF exhibited DPPH and ABTS radical scavenging activities. In addition, FF showed high levels of total polyphenol and total flavonoids. Body and organ weight and dietary intake were significantly decreased in the FF groups compared to the HFD group. The FF group showed improved recovery in lipid metabolism and liver function compared to the HFD group. In addition, the FF group showed a significant decrease in serum C-P and insulin concentrations compared to the HFD group. FF-administered mice showed a dose-dependent recovery of fasting blood glucose and IPGTT and AUC levels compared to the HFD group. Furthermore, FF groups showed a decreased expression in FAS, C/EBPα, and FABP4, as well as significantly increased expression in ACC in the liver. This study demonstrates that FF is effective in reducing and inhibiting adipogenesis as well as lowering body weight, the blood glucose level, and lipid-related factors. These research findings demonstrate that FF is effective in treating obesity and diabetes.
ISSN:2076-3417
2076-3417
DOI:10.3390/app14156412