In-vitro release studies of ciprofloxacin drug using polyaniline/polypyrrole-encapsulated β-cyclodextrin nanocomposites

• Published in: Polymer bulletin (Berlin, Germany) Vol. 80; no. 12; pp. 12557 - 12576
• Main Authors: Zia, Jannatun, Riyazuddin, Mohd, Jackson, Shaila, Taylor, Darlene K., Riaz, Ufana
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2023; Springer Nature B.V
• Subjects: Adsorption; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Conducting polymers; Cyclodextrins; Drug delivery systems; Infrared spectroscopy; Morphology; Nanocomposites; Organic Chemistry; Original Paper; Physical Chemistry; Polyanilines; Polymer Sciences; Polymerization; Polymers; Polypyrroles; Scanning electron microscopy; Soft and Granular Matter; Sustained release; Ultrasonic imaging; Ultraviolet spectra; India; Drug release kinetics; Adsorption; Polyaniline; Ciprofloxacin; β-cyclodextrin; Polypyrrole
• ISSN: 0170-0839; 1436-2449
• DOI: 10.1007/s00289-022-04667-4

The present study reports the synthesis of nanocomposites of β-cyclodextrin (β-CD) with polyaniline (PANI) and polypyrrole (PPy) to design core–shell nanocomposites. The synthesized nanocomposites were investigated for their spectral, morphological and thermal characteristics. IR spectra confirmed the incorporation of PANI and PPy in β-CD by the strong interaction between NH of PANI/PPY and OH of β-CD, while the ultraviolet (UV)-visible spectra confirmed the polaronic state of conducting polymers in the nanocomposites. The scanning electron microscopy (SEM) analysis revealed the core–shell like morphology of the nanocomposites. Ciprofloxacin (CIP) was chosen as a model drug to study the in-vitro drug release as gastric (pH 1.2) and intestinal (pH 7.4) values by loading the drug (50 mg) into the pristine polymers as well as β-CD nanocomposites. The nanocomposites were found to show the sustained release behavior and hold potential to be used as an effective antibiotic drug delivery vehicle.