Fabrication and characterization of nano-particle biomaterial scaffold for treating burn wounds

Healing burn wounds is a complex process and challenging to design an ideal scaffold for tissue regeneration. The inflammatory phase is critical in the healing of burn wounds due to the presence of bacteria and/or endotoxins. This research deals with the fabrication and development of electrospun me...

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Bibliographic Details
Published inJournal of materials research Vol. 37; no. 23; pp. 4360 - 4367
Main Authors Ramkumar, S., Nivetha, A. S., Saravanan, S., Harchana, R., Sathyasri, B., Sammeta, Naresh
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 14.12.2022
Springer Nature B.V
Subjects
Antiinfectives and antibacterials
Applied and Technical Physics
Bacteria
Biocompatibility
Biomaterials
Biomedical materials
Cell adhesion
Chemistry and Materials Science
Endotoxins
Inorganic Chemistry
Materials Engineering
Materials research
Materials Science
Metal oxides
Nanofibers
Nanoparticles
Nanotechnology
Polyvinyl alcohol
Regeneration (physiology)
Scaffolds
Structural analysis
Tissue engineering
Wound healing
Burns
Scaffolding
Nanoparticle
Wound
Fabricated
Molybdenum
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Summary:Healing burn wounds is a complex process and challenging to design an ideal scaffold for tissue regeneration. The inflammatory phase is critical in the healing of burn wounds due to the presence of bacteria and/or endotoxins. This research deals with the fabrication and development of electrospun metal oxide nanoparticle incorporated polyvinyl alcohol nanofiber in the healing of second-degree burn wounds. Structural and Physico-chemical characterization of the scaffold was performed. Structural analysis is performed to confirm the incorporation of the Molybdenum nanoparticle into the PVA scaffold. The biocompatibility and cellular adhesion of the fabricated scaffold are analyzed quantitatively by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay and crystal violet assay, respectively. Antimicrobial activity is tested for PVA scaffold against both gram-positive and gram-negative bacteria. Our results, therefore, open up a new avenue for designing a nanoparticle incorporated delivery system in wound therapeutics, especially for second-degree burns. Graphical abstract
ISSN:0884-2914
2044-5326
DOI:10.1557/s43578-022-00807-8