Postmortem Memantine Concentrations

Postmortem fluid and tissue concentrations of memantine (Namenda™), a drug recently approved for the treatment of Alzheimer's Disease by the FDA, are reported in a suspicious death. In addition, memantine concentrations considered to be incidental findings in three other cases are included to a...

Full description

Saved in:
Bibliographic Details
Published inJournal of analytical toxicology Vol. 31; no. 4; pp. 233 - 236
Main Authors Bynum, Nichole, Poklis, Justin, Garside, Diana, Winecker, Ruth
Format Journal Article
LanguageEnglish
Published Niles, IL Oxford University Press 01.05.2007
Preston
Subjects
Alzheimer Disease - drug therapy
Biological and medical sciences
Cause of Death
Drug intoxications. Doping
Drug Overdose
Excitatory Amino Acid Antagonists - analysis
Excitatory Amino Acid Antagonists - blood
Excitatory Amino Acid Antagonists - poisoning
Excitatory Amino Acid Antagonists - urine
Forensic Toxicology
Gas Chromatography-Mass Spectrometry
Humans
Liver - chemistry
Male
Medical sciences
Memantine - analysis
Memantine - blood
Memantine - poisoning
Memantine - urine
Middle Aged
Pharmacology. Drug treatments
Vitreous Body - chemistry
Human
Biological fluid
Chemical analysis
Liquid liquid extraction
Coupled method
Drug intoxication
Postmortem
Glutamate receptor
Forensic aspect
Solvent extraction
Autopsy material
Antiparkinson agent
Gas chromatography
Tissue
Memantine
Sample preparation
Distribution
Overdose
Antagonist
NMDA receptor
Mass spectrometry
Quantitative analysis
Online AccessGet full text

Cover

More Information
Summary:Postmortem fluid and tissue concentrations of memantine (Namenda™), a drug recently approved for the treatment of Alzheimer's Disease by the FDA, are reported in a suspicious death. In addition, memantine concentrations considered to be incidental findings in three other cases are included to aid in the interpretation in future toxicological investigations. Memantine was extracted from biological samples by a standard liquid-liquid basic drug method followed by analysis utilizing a gas chromatograph-mass spectrometer operated in SIM mode. Blood concentrations ranged from 0.03 to 1.8 mg/L, and the liver concentration was 6.1 mg/kg.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/31.4.233