Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807

Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheim...

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Bibliographic Details
Published inJournal of Alzheimer's disease Vol. 34; no. 2; p. 457
Main Authors Chien, David T, Bahri, Shadfar, Szardenings, A Katrin, Walsh, Joseph C, Mu, Fanrong, Su, Min-Ying, Shankle, William R, Elizarov, Arkadij, Kolb, Hartmuth C
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2013
Subjects
Aged
Aged, 80 and over
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - metabolism
Carbolines - metabolism
Early Diagnosis
Female
Fluorine Radioisotopes - metabolism
Frontal Lobe - diagnostic imaging
Frontal Lobe - metabolism
Humans
Male
Middle Aged
Phosphorylation - physiology
Positron-Emission Tomography - methods
tau Proteins - metabolism
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Summary:Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer's disease and other tauopathies. Here in, we describe the first human brain images with [F-18]-T807.
ISSN:1875-8908
DOI:10.3233/JAD-122059