When Shigella Tells the Cell to Hang On

OspE, a Shigella type III effector binds to integrin-like kinase and enhances cell adhesion to better disseminate and colonize the intestinal epithelium. Because of the existence of OspE orthologues in other enteropathogens such as enteropathogenic Escherichia coli or Salmonella sp., maintenance of...

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Bibliographic Details
Published inJournal of molecular cell biology Vol. 1; no. 2; pp. 64 - 65
Main Authors Tran Van Nhieu, Guy, Guignot, Julie
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 01.12.2009
Subjects
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Focal Adhesions - microbiology
Gene Expression Regulation, Bacterial
Host-Pathogen Interactions
Humans
Shigella - genetics
Shigella - pathogenicity
Shigella - physiology
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Summary:OspE, a Shigella type III effector binds to integrin-like kinase and enhances cell adhesion to better disseminate and colonize the intestinal epithelium. Because of the existence of OspE orthologues in other enteropathogens such as enteropathogenic Escherichia coli or Salmonella sp., maintenance of cell adhesion appears as a widespread strategy for bacteria that interact with the intestinal epithelium.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1674-2788
1759-4685
DOI:10.1093/jmcb/mjp013