Synthesis of Graphene Oxide/Iron Oxide/Au Nanocomposite for Quercetin Delivery

This study focused on developing a superparamagnetic graphene oxide-based nanocomposite consisting of iron oxide (IO) and gold nanoparticles for quercetin delivery. For this purpose, the structure and morphology of the designed nanocomposite (GO/IO/Au) were investigated by several characterization m...

Full description

Saved in:
Bibliographic Details
Published inJournal of inorganic and organometallic polymers and materials Vol. 32; no. 5; pp. 1541 - 1550
Main Authors Saqezi, Azita Sharifi, Kermanian, Mehraneh, Ramazani, Ali, Sadighian, Somayeh
Format Journal Article
LanguageEnglish
Published New York Springer US 2022
Springer Nature B.V
Subjects
Artemia
Assaying
Biocompatibility
Biomedical materials
Chemistry
Chemistry and Materials Science
Drug carriers
Drug delivery systems
Electron microscopy
Emission analysis
Erythrocytes
Field emission microscopy
Fourier transforms
Gold
Graphene
Infrared analysis
Infrared spectroscopy
Inorganic Chemistry
Iron oxides
Lethality
Microscopy
Nanocomposites
Nanoparticles
Organic Chemistry
Polymer Sciences
Graphene oxide
Drug delivery
Iron oxide
Gold nanoparticles
Quercetin
Online AccessGet full text

Cover

More Information
Summary:This study focused on developing a superparamagnetic graphene oxide-based nanocomposite consisting of iron oxide (IO) and gold nanoparticles for quercetin delivery. For this purpose, the structure and morphology of the designed nanocomposite (GO/IO/Au) were investigated by several characterization methods such as fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) analysis, vibrating-sample magnetometer (VSM) analysis, field emission scanning electron microscopy (FESEM) and Transmission electron microscopy (TEM). Then, the biocompatibility of the synthesized nanocomposite was studied by Brine shrimp Artemia lethality assay, red blood cell hemolysis assay, and MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. Moreover, the GO/IO/Au nanocomposite efficiency as an anticancer drug delivery system was evaluated in vitro conditions. The results showed that the designed nanocomposite is highly biocompatible and possesses a favorable magnetization ( M s  = 29.2 emu.g −1 ) making it a good candidate for biomedical applications. Also, it was confirmed that GO/IO/Au nanocomposite is a potent drug carrier that can effectively deliver quercetin to cancer cells.
ISSN:1574-1443
1574-1451
DOI:10.1007/s10904-022-02259-3