Little contribution of GB virus C to the development of primary hepatocellular carcinoma in Japan

RNA of GB virus C was searched for in sera from 109 patients with primary hepatocellular carcinoma. It was detected in 11 patients (10%), and was more frequent than in 3 of 342 blood donors (0.9%) (P < 0.001). The 11 patients included 4 of 29 patients (14%) with hepatitis B surface antigen and 7...

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Bibliographic Details
Published inJournal of gastroenterology Vol. 34; no. 4; pp. 494 - 497
Main Authors Nishiyama, Y, Hino, K, Sawada, N, Tsuda, F
Format Journal Article
LanguageEnglish
Published Japan 01.08.1999
Subjects
Carcinoma, Hepatocellular - virology
Female
Flaviviridae - isolation & purification
Hepacivirus - isolation & purification
Hepatitis B Antibodies - blood
Hepatitis B Surface Antigens - blood
Hepatitis C Antibodies - blood
Hepatitis, Viral, Human - blood
Hepatitis, Viral, Human - complications
Hepatitis, Viral, Human - epidemiology
Humans
Japan
Liver Neoplasms - virology
Male
Middle Aged
Prevalence
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - blood
Japan
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Summary:RNA of GB virus C was searched for in sera from 109 patients with primary hepatocellular carcinoma. It was detected in 11 patients (10%), and was more frequent than in 3 of 342 blood donors (0.9%) (P < 0.001). The 11 patients included 4 of 29 patients (14%) with hepatitis B surface antigen and 7 of 74 patients (9%) with antibody to hepatitis C virus. RNA of GB virus C was not detected in any of 4 patients without hepatitis B surface antigen or antibody to hepatitis C virus. These results suggest that GB virus C may contribute little to the development of primary hepatocellular carcinoma in Japan.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0944-1174
1435-5922
DOI:10.1007/s005350050302