Evidence that mouse astrocytes may be derived from the radial glia: an immunohistochemical study of the cerebellum in the normal and reeler mouse

• Published in: Journal of neuroimmunology Vol. 9; no. 1-2; pp. 87 - 97
• Main Authors: BENJELLOUN-TOUIMI, S, JACQUE, C. M, DERER, P, DE VITRY, F, MAUNOURY, R, DUPOUEY, P
• Format: Journal Article
• Language: English
• Published: London Elsevier 01.01.1985; Amsterdam; New York, NY
• Subjects: Anatomy; Animals; Antibodies - analysis; Astrocytes - cytology; Biological and medical sciences; Central nervous system; Cerebellum - ultrastructure; Fundamental and applied biological sciences. Psychology; Glial Fibrillary Acidic Protein - immunology; Histocytochemistry; Immunochemistry; Mice; Mice, Neurologic Mutants; Neuroglia - ultrastructure; S100 Proteins - immunology; Staining and Labeling; Vertebrates: nervous system and sense organs; Vimentin - immunology; Cerebellum; Immunohistochemistry; Vertebrata; Glial fribrillary acidic protein; Mammalia; Mouse; Rodentia; Central nervous system; Brain (Vertebrata); Astrocyte; Cell differentiation; Neurological mutation
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/S0165-5728(85)80009-6

Astrocytic cells of unusual aspect can be detected in the cerebellum of normal mice during the first 4 weeks of life. They are visualized with anti-GFAP (glial fibrillary acidic protein), anti-S100 and anti-vimentin immune sera. Their perikaryons, located in the white matter or in the granular layer, extend long processes which are inserted onto the pial surface. These cells may be transitional forms between the radial glial cells and some of the differentiated astroglial elements. These unusual astrocytes are more numerous and heavily stained in the reeler mutant than in the normal mouse and it is suggested that our observations signify some degree of glial immaturity in the cerebellum of the mutant.