Dynamic MR Imaging of the Biliary System Using Hepatocyte-Specific Contrast Agents
The objective of our study was to illustrate how the properties of hepatocyte-specific MR contrast agents can be used in the dynamic evaluation of the biliary system. Because of their dual route of excretion through the kidneys and the liver, gadolinium-based, hepatocyte-specific MR contrast agents...
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Published in | American journal of roentgenology (1976) Vol. 195; no. 2; pp. 405 - 413 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Reston, VA
American Roentgen Ray Society
01.08.2010
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Abstract | The objective of our study was to illustrate how the properties of hepatocyte-specific MR contrast agents can be used in the dynamic evaluation of the biliary system.
Because of their dual route of excretion through the kidneys and the liver, gadolinium-based, hepatocyte-specific MR contrast agents can be used to evaluate the biliary tract as an off-label use. Images are obtained during the hepatocyte phase, which usually occurs within 20-40 minutes after injection depending on the specific contrast agent selected. Potential uses include showing variant biliary anatomy and choledocholithiasis. Evaluation for acute cholecystitis is possible by assessing for reflux of contrast material across the cystic duct. Additionally, these agents have value in both presurgical and postsurgical imaging for showing anatomy and complications. Finally, these agents are useful in the evaluation of choledochal cysts. |
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AbstractList | The objective of our study was to illustrate how the properties of hepatocyte-specific MR contrast agents can be used in the dynamic evaluation of the biliary system.
Because of their dual route of excretion through the kidneys and the liver, gadolinium-based, hepatocyte-specific MR contrast agents can be used to evaluate the biliary tract as an off-label use. Images are obtained during the hepatocyte phase, which usually occurs within 20-40 minutes after injection depending on the specific contrast agent selected. Potential uses include showing variant biliary anatomy and choledocholithiasis. Evaluation for acute cholecystitis is possible by assessing for reflux of contrast material across the cystic duct. Additionally, these agents have value in both presurgical and postsurgical imaging for showing anatomy and complications. Finally, these agents are useful in the evaluation of choledochal cysts. OBJECTIVEThe objective of our study was to illustrate how the properties of hepatocyte-specific MR contrast agents can be used in the dynamic evaluation of the biliary system.CONCLUSIONBecause of their dual route of excretion through the kidneys and the liver, gadolinium-based, hepatocyte-specific MR contrast agents can be used to evaluate the biliary tract as an off-label use. Images are obtained during the hepatocyte phase, which usually occurs within 20-40 minutes after injection depending on the specific contrast agent selected. Potential uses include showing variant biliary anatomy and choledocholithiasis. Evaluation for acute cholecystitis is possible by assessing for reflux of contrast material across the cystic duct. Additionally, these agents have value in both presurgical and postsurgical imaging for showing anatomy and complications. Finally, these agents are useful in the evaluation of choledochal cysts. |
Author | GUPTA, Rajan T BRADY, Christopher M LOTZ, Joachim BOLL, Daniel T MERKLE, Elmar M |
Author_xml | – sequence: 1 givenname: Rajan T surname: GUPTA fullname: GUPTA, Rajan T organization: Department of Radiology, Duke University Medical Center, DUMC 3808, Durham, NC 27710, United States – sequence: 2 givenname: Christopher M surname: BRADY fullname: BRADY, Christopher M organization: Department of Radiology, Duke University Medical Center, DUMC 3808, Durham, NC 27710, United States – sequence: 3 givenname: Joachim surname: LOTZ fullname: LOTZ, Joachim organization: Department of Radiology, University Medical Center Göttingen, Göttingen, Germany – sequence: 4 givenname: Daniel T surname: BOLL fullname: BOLL, Daniel T organization: Department of Radiology, Duke University Medical Center, DUMC 3808, Durham, NC 27710, United States – sequence: 5 givenname: Elmar M surname: MERKLE fullname: MERKLE, Elmar M organization: Department of Radiology, Duke University Medical Center, DUMC 3808, Durham, NC 27710, United States |
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Keywords | Human Biliary tract hepatobiliary system Hepatocyte hepatocyte-specific MR contrast agents Digestive system MRI Medical imagery Nuclear magnetic resonance imaging Dynamic method Contrast media |
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Snippet | The objective of our study was to illustrate how the properties of hepatocyte-specific MR contrast agents can be used in the dynamic evaluation of the biliary... OBJECTIVEThe objective of our study was to illustrate how the properties of hepatocyte-specific MR contrast agents can be used in the dynamic evaluation of the... |
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SubjectTerms | Biliary Tract - pathology Biliary Tract Diseases - pathology Biological and medical sciences Contrast Media Digestive system Drug Delivery Systems - methods Gadolinium Hepatocytes - pathology Humans Image Enhancement - methods Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Medical sciences Radiodiagnosis. Nmr imagery. Nmr spectrometry |
Title | Dynamic MR Imaging of the Biliary System Using Hepatocyte-Specific Contrast Agents |
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