Dynamic MR Imaging of the Biliary System Using Hepatocyte-Specific Contrast Agents

• Published in: American journal of roentgenology (1976) Vol. 195; no. 2; pp. 405 - 413
• Main Authors: GUPTA, Rajan T, BRADY, Christopher M, LOTZ, Joachim, BOLL, Daniel T, MERKLE, Elmar M
• Format: Journal Article
• Language: English
• Published: Reston, VA American Roentgen Ray Society 01.08.2010
• Subjects: Biliary Tract - pathology; Biliary Tract Diseases - pathology; Biological and medical sciences; Contrast Media; Digestive system; Drug Delivery Systems - methods; Gadolinium; Hepatocytes - pathology; Humans; Image Enhancement - methods; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging - methods; Medical sciences; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Human; Biliary tract; hepatobiliary system; Hepatocyte; hepatocyte-specific MR contrast agents; Digestive system; MRI; Medical imagery; Nuclear magnetic resonance imaging; Dynamic method; Contrast media
• ISSN: 0361-803X; 1546-3141
• DOI: 10.2214/AJR.09.3641

The objective of our study was to illustrate how the properties of hepatocyte-specific MR contrast agents can be used in the dynamic evaluation of the biliary system. Because of their dual route of excretion through the kidneys and the liver, gadolinium-based, hepatocyte-specific MR contrast agents can be used to evaluate the biliary tract as an off-label use. Images are obtained during the hepatocyte phase, which usually occurs within 20-40 minutes after injection depending on the specific contrast agent selected. Potential uses include showing variant biliary anatomy and choledocholithiasis. Evaluation for acute cholecystitis is possible by assessing for reflux of contrast material across the cystic duct. Additionally, these agents have value in both presurgical and postsurgical imaging for showing anatomy and complications. Finally, these agents are useful in the evaluation of choledochal cysts.