A study of the morphological changes in the small intestine of the spontaneously diabetic Chinese hamster

Several morphological changes were observed microscopically in the small intestine of some diabetic Chinese hamsters. Although some alterations lacked statistical significance due to variation, most diabetics displayed a greater incidence and severity compared with nondiabetic controls. The followin...

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Bibliographic Details
Published inDiabetologia Vol. 12; no. 2; p. 101
Main Authors Diani, A R, Gerritsen, G C, Stromsta, S, Murray, P
Format Journal Article
LanguageEnglish
Published Germany 01.05.1976
Subjects
Animals
Blood Vessels - pathology
Cricetinae
Diabetes Mellitus - pathology
Intestinal Mucosa - pathology
Intestine, Small - blood supply
Intestine, Small - pathology
Lymphocytes - pathology
Muscle, Smooth - pathology
Myenteric Plexus - pathology
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Summary:Several morphological changes were observed microscopically in the small intestine of some diabetic Chinese hamsters. Although some alterations lacked statistical significance due to variation, most diabetics displayed a greater incidence and severity compared with nondiabetic controls. The following structural deviations were seen in the small intestines of some diabetics: increased surface area, elevated number of goblet cells per villus, decreased muscle thickness with connective tissue infiltration, reduced number of Auerbach's plexuses, lymphocyte aggregations accompanied by blunted villi, blood vascular lesions and deformed villi due to excessive loss of epithelial cells.
ISSN:0012-186X
DOI:10.1007/BF00428973