Green and chemo selective amine methylation using methanol by an organometallic ruthenium complex

• Published in: Journal of organometallic chemistry Vol. 957; p. 122155
• Main Authors: Dindar, Sara, Nemati Kharat, Ali, Abbasi, Alireza
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2022
• Subjects: Methanol; N-methylation; Pincer POP ligand; Ruthenium carbonyl complex; Xantphos ligand; Xantphos ligand; N-methylation; Pincer POP ligand; Ruthenium carbonyl complex; Methanol
• ISSN: 0022-328X; 1872-8561
• DOI: 10.1016/j.jorganchem.2021.122155

•Synthesis and crystal structure of a novel ruthenium carbonyl complex, RuCl2(CO)(Xantphos) with a trident pincer mode for xanphos ligand.•Obtain a green and atom-efficient process for n-methylation amine with methanol under hydrogen autotransfer conditions.•High active and chemo-selective homougenous catalytic system for N-methylation of aniline and hexylamine. Herein a green and convenient catalytic N-methylation of aniline and n-hexylamine using methanol as a dual methylation agent and solvent has been investigated. A new ruthenium carbonyl complex was synthesized and applied as a homogeneous catalyst in methylation reaction. The solid-state structure of the complex was determined by X-ray crystallographic analysis which indicate xantphos ligand bonded to ruthenium (II) as a tridentate pincer ligand by two P donor and one O atom. The catalytic system showed excellent conversion and selectivity toward N-methylaniline, and N,N-hexyldimethylamine at 140°C. [Display omitted]