Patient-specific optimal cooling power command for hypothermia induction by liquid ventilation

• Published in: Control engineering practice Vol. 77; pp. 109 - 117
• Main Authors: Nadeau, Mathieu, Denaclara, Jean-Yves, Tissier, Renaud, Walti, Herve, Micheau, Philippe
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.08.2018
• Subjects: Direct optimal control; Hypothermia induction; Liquid ventilation; Thermal modeling; Time-varying non-linear model; Hypothermia induction; Direct optimal control; Liquid ventilation; Thermal modeling; Time-varying non-linear model

While it is known that total liquid ventilation can rapidly cool animal subjects and improve outcomes after cardiac arrest, the temperature control strategy of the liquid ventilator for clinical use remains unknown. This work proposes to control the cooling power of the liquid ventilator in two phas...