Patient-specific optimal cooling power command for hypothermia induction by liquid ventilation

• Published in: Control engineering practice Vol. 77; pp. 109 - 117
• Main Authors: Nadeau, Mathieu, Denaclara, Jean-Yves, Tissier, Renaud, Walti, Herve, Micheau, Philippe
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.08.2018
• Subjects: Direct optimal control; Hypothermia induction; Liquid ventilation; Thermal modeling; Time-varying non-linear model; Hypothermia induction; Direct optimal control; Liquid ventilation; Thermal modeling; Time-varying non-linear model
• ISSN: 0967-0661; 1873-6939
• DOI: 10.1016/j.conengprac.2018.05.007

While it is known that total liquid ventilation can rapidly cool animal subjects and improve outcomes after cardiac arrest, the temperature control strategy of the liquid ventilator for clinical use remains unknown. This work proposes to control the cooling power of the liquid ventilator in two phases. The first phase consists in a null cooling power command in order to estimate cardiac output. During the second phase, the optimal cooling power command dedicated to the estimated cardiac output is sent to the cooling system. The simulated results in human adults allow predicting the cooling performances and the overall safety. •Cooling power command for liquid ventilated post-cardiac arrest patients is developed.•Specific-patient power command involves two phases due to uncertain cardiac output.•First phase is passive to estimate the cardiac output using the expired temperature.•Second phase is a direct optimal cooling power command with the estimated parameter.•The cooling commands can safely and rapidly cool any post-cardiac arrest patient.