Automatic regulatory control in type 1 diabetes without carbohydrate counting

A new approach to automatically regulate the glucose level in type 1 diabetes is presented in this work. This is the so-called Automatic Regulation of Glucose (ARG) algorithm, which is based on a switched Linear Quadratic Gaussian (LQG) inner controller, combined with an outer sliding mode safety lo...

Full description

Saved in:
Bibliographic Details
Published inControl engineering practice Vol. 74; pp. 22 - 32
Main Authors Colmegna, Patricio, Garelli, Fabricio, De Battista, Hernán, Sánchez-Peña, Ricardo
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.05.2018
Subjects
Artificial pancreas
Glucose control
Insulin on board
Sliding mode control
Switched LQG control
Artificial pancreas
Switched LQG control
Insulin on board
Sliding mode control
Glucose control
Online AccessGet full text

Cover

More Information
Summary:A new approach to automatically regulate the glucose level in type 1 diabetes is presented in this work. This is the so-called Automatic Regulation of Glucose (ARG) algorithm, which is based on a switched Linear Quadratic Gaussian (LQG) inner controller, combined with an outer sliding mode safety loop with Insulin on Board (IOB) constraints. In silico and in vivo results without feedforward insulin boluses delivered at meal times indicate that safe blood glucose control can be achieved by the proposed controller. This controller is simple to migrate to well-known hardware platforms, and intuitive to tune using a priori clinical information.
ISSN:0967-0661
1873-6939
DOI:10.1016/j.conengprac.2018.02.003