Mediated self-assembly of host-guest nano copper cyanide and 1,7-diaminoheptane: Design, catalytic and biological evaluation

• Published in: Journal of organometallic chemistry Vol. 951; p. 122011
• Main Authors: Badr El-din, Ahmed S., Abd El-Aziz, Dina M., Khattab, Hayam M., Etaiw, Safaa El-din H.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.10.2021
• Subjects: 1,7-diaminoheptane; Biological activity; Catalytic activity; Crystal structure; Cuprous cyanide; Host-guest system; Catalytic activity; Cuprous cyanide; Host-guest system; 1,7-diaminoheptane; Biological activity; Crystal structure
• ISSN: 0022-328X; 1872-8561
• DOI: 10.1016/j.jorganchem.2021.122011

•3D-host-guest supramolecular coordination polymer (SCP1); ∞3[(Cu3(CN)3)2.(DAHP)], was synthesized by self-assembly method under ultrasonic radiation.•Structure consists of new two-fold [Cu3(CN)3]2 fragments containing tetrahedral copper(I) atoms which are arranged in unique way to create 3D-structure containing DAHP as guest molecule.•The nano-system exhibits excellent catalytic activity towards mineralization of methyl violet, methylene blue and indigo carmine dyes using H2O2 as oxidant within very short time.•The activity against some human cancer cell lines, antimicrobial activity, and antioxidant activities have been evaluated. Long chain aliphatic diamine, 1,7-diaminoheptane (DAHP), was selected as template for creation of novel nano-scaled 3D-guest-host- supramolecular coordination polymer (SCP); ∞3[(Cu3(CN)3)2.(DAHP)], 1. Crystal structure of SCP 1 consists of new bi-fold [Cu3(CN)3]2 fragments containing tetrahedral copper(I) atoms which are arranged in unique way to create 3D-structure exhibiting wide cavities enable to encapsulate the long chain DAHP as guest molecule. The topology of 1 had been elucidated by spectroscopic methods, elemental analysis, transmission electron microscopy (TEM) and scanning electron microscope (SEM). The nanosized SCP1 exhibits excellent catalytic activity towards mineralization of methyl violet (MV), methylene blue (MB) and indigo carmine (IC) dyes using H2O2 as oxidant within very short times. Scavenger techniques and disodium terephthalate (NaTA) as selective photoluminescence prob of hydroxyl radical had been utilized to elucidate mineralization mechanism. Nano-SCP 1 exhibits sigmoidal dose-response inhibition of cells viability giving low IC50 values for the tested cell as well as was examined for rate erythrocyte hemolysis and antioxidant activity utilizing ABTS assay. Also, SCP1 exhibits good antimicrobial activity due to the low MIC values keeping it a promising drug candidate for the treatment of the tested bacterial and fungal infections. [Display omitted]