Tumor-detecting capacity and clinical usefulness of SPIO-MRI in patients with hepatocellular carcinoma

The tumor-detecting capacity and clinical usefulness of superparamagnetic iron oxide (SPIO) magnetic resonance imaging (MRI) were examined in patients with hepatocellular carcinoma. The tumor detection rate of SPIO-MRI (64.5%) was comparable to those of dynamic computed tomography (CT) and plain MRI...

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Bibliographic Details
Published inJournal of gastroenterology Vol. 35; no. 11; pp. 849 - 855
Main Authors Nakamura, H, Ito, N, Kotake, F, Mizokami, Y, Matsuoka, T
Format Journal Article
LanguageEnglish
Published Japan 2000
Subjects
Aged
Carcinoma, Hepatocellular - diagnosis
Contrast Media
Dextrans
Female
Ferrosoferric Oxide
Gadolinium
Humans
Iron
Liver - pathology
Liver Neoplasms - diagnosis
Magnetic Resonance Imaging
Magnetite Nanoparticles
Male
Middle Aged
Oxides
Tomography, X-Ray Computed
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Summary:The tumor-detecting capacity and clinical usefulness of superparamagnetic iron oxide (SPIO) magnetic resonance imaging (MRI) were examined in patients with hepatocellular carcinoma. The tumor detection rate of SPIO-MRI (64.5%) was comparable to those of dynamic computed tomography (CT) and plain MRI, but lower than that for Gd dynamic MRI (93.5%; P < 0.01%). A combination of Gd dynamic MRI and SPIO-MRI improved the detection rate; further, the tumor stage with respect to tumor blood-flow pattern was predicted by combining plain MRI with SPIO-MRI. This combination procedure may also be useful for selecting therapeutic strategies.
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ISSN:0944-1174
1435-5922
DOI:10.1007/s005350070022