Induced pluripotent stem cells and personalized medicine: current progress and future perspectives

Generation of induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. iPSCs can self-renew and can differentiate into many cell types, offering a potentially unlimited so...

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Bibliographic Details
Published inAnatomy & cell biology Vol. 44; no. 4; pp. 245 - 255
Main Authors Chun, Yong Soon, Byun, Kyunghee, Lee, Bonghee
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Association of Anatomists 01.12.2011
대한해부학회
Subjects
Review
해부학
Induced pluripotent stem cell
Disease modeling
Genomics
Proteomics
Online AccessGet full text
ISSN2093-3665
2093-3673
2093-3673
DOI10.5115/acb.2011.44.4.245

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Summary:Generation of induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. iPSCs can self-renew and can differentiate into many cell types, offering a potentially unlimited source of cells for targeted differentiation into somatic effector cells. Hence, iPSCs are likely to be invaluable for therapeutic applications and disease-related research. In this review, we summarize the recent progress of iPSC generation that has been made with an emphasis on both basic and clinical applications including disease modeling, drug toxicity screening/drug discovery and cell replacement therapy.
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G704-000177.2011.44.4.001
ISSN:2093-3665
2093-3673
2093-3673
DOI:10.5115/acb.2011.44.4.245