Synthesis of oligonucleotides possessing versatile probes for PET labelling and their rapid ligand-free click reaction

We synthesised aryl acetylene derivatives as versatile probes for labelling of oligonucleotides. RNA oligomers bearing an aryl acetylene molecule rapidly reacted with benzylazide derivatives under ligand-free click reaction conditions.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 47; no. 9; pp. 2691 - 2693
Main Authors Shiraishi, Takao, Kitamura, Yoshiaki, Ueno, Yoshihito, Kitade, Yukio
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2011
Subjects
Acetylene - chemistry
Alkynes - chemistry
Azides - chemistry
Catalysis
Chemistry
Chemistry, Multidisciplinary
Click Chemistry
Copper - chemistry
Ligands
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Physical Sciences
Positron-Emission Tomography
RNA - chemistry
Science & Technology
2-5A
AZIDE-ALKYNE CYCLOADDITION
POSITRON-EMISSION-TOMOGRAPHY
RIBONUCLEASE-L
TERMINAL ALKYNES
SIRNAS
HUMAN RNASE-L
NUCLEIC-ACIDS
MOLECULES
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Summary:We synthesised aryl acetylene derivatives as versatile probes for labelling of oligonucleotides. RNA oligomers bearing an aryl acetylene molecule rapidly reacted with benzylazide derivatives under ligand-free click reaction conditions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc04979d