Iohexol and metrizamide in lumbar myelography. Comparison of side effects

In routine lumbar myelography carried out in 100 patients iohexol (n = 50) produced side effects in fewer patients (p less than 0.03), especially meningeal and cerebral (p less than 0.03), and among these a lower rate of headache (p less than 0.07), than did metrizamide. The overall frequency of aff...

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Bibliographic Details
Published inActa radiologica. Diagnosis Vol. 26; no. 6; p. 761
Main Author Laasonen, E M
Format Journal Article
LanguageEnglish
Published Sweden 01.11.1985
Subjects
Clinical Trials as Topic
Contrast Media - adverse effects
Humans
Iodobenzoates - adverse effects
Iohexol
Metrizamide - adverse effects
Myelography - methods
Prospective Studies
Random Allocation
Time Factors
Triiodobenzoic Acids - adverse effects
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Summary:In routine lumbar myelography carried out in 100 patients iohexol (n = 50) produced side effects in fewer patients (p less than 0.03), especially meningeal and cerebral (p less than 0.03), and among these a lower rate of headache (p less than 0.07), than did metrizamide. The overall frequency of afflicted patients (50% after iohexol and 72% after metrizamide) was high, mainly because of deliberate inclusion of patients with a high risk of side effects in the investigation. The side effects recorded up to six hours after the administration of the contrast medium were less frequent when using iohexol. If severe side effects are present at 24 hours or appear thereafter, as occurred in a few of the present patients after iohexol, surgical treatment or discharge of the patient is in some cases unnecessarily delayed.
ISSN:0567-8056
DOI:10.1177/028418518502600623