MADOR: a new tool to calculate decrease of effective doses in human after DTPA therapy

Abstract models have been developed to describe dissolution of Pu/Am/Cm after internal contamination by inhalation or wound, chelation of actinides by diethylene triamine penta acetic acid (DTPA) in different retention compartments and excretion of actinide-DTPA complexes. After coupling these model...

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Bibliographic Details
Published inRadiation protection dosimetry Vol. 144; no. 1-4; p. 371
Main Authors Fritsch, P, Grémy, O, Hurtgen, C, Bérard, P, Grappin, L, Poncy, J L
Format Journal Article
LanguageEnglish
Published England 01.03.2011
Subjects
Actinoid Series Elements - analysis
Algorithms
Bile
Chelating Agents - chemistry
Computer Simulation
Feces
Humans
Liver - metabolism
Models, Biological
Models, Theoretical
Pentetic Acid - therapeutic use
Radiation Injuries - drug therapy
Radiation Protection - methods
Radiation-Protective Agents - administration & dosage
Urine
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Summary:Abstract models have been developed to describe dissolution of Pu/Am/Cm after internal contamination by inhalation or wound, chelation of actinides by diethylene triamine penta acetic acid (DTPA) in different retention compartments and excretion of actinide-DTPA complexes. After coupling these models with those currently used for dose calculation, the modelling approach was assessed by fitting human data available in IDEAS database. Good fits were obtained for most studied cases, but further experimental studies are needed to validate some modelling hypotheses as well as the range of parameter values. From these first results, radioprotection tools are being developed: MAnagement of DOse Reduction after DTPA therapy.
ISSN:1742-3406
DOI:10.1093/rpd/ncq429