Efficient and accessible silane-mediated direct amide coupling of carboxylic acids and amines
A straightforward method for the direct synthesis of amides from amines and carboxylic acids without exclusion of air or moisture using diphenylsilane with N -methylpyrrolidine has been developed. Various amides are made efficiently, and broad functional group compatibility is shown through a Gloriu...
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Published in | Green chemistry : an international journal and green chemistry resource : GC Vol. 23; no. 1; pp. 288 - 295 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
18.01.2021
Royal Society of Chemistry |
Subjects | |
Online Access | Get full text |
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Summary: | A straightforward method for the direct synthesis of amides from amines and carboxylic acids without exclusion of air or moisture using diphenylsilane with
N
-methylpyrrolidine has been developed. Various amides are made efficiently, and broad functional group compatibility is shown through a Glorius robustness study. A gram-scale synthesis demonstrates the scalability of this method.
A highly practical method for the direct coupling of amines and unactivated carboxylic acids to form amides. |
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Bibliography: | Electronic supplementary information (ESI) available. See DOI 10.1039/d0gc02833a |
ISSN: | 1463-9262 1463-9270 |
DOI: | 10.1039/d0gc02833a |