Selective bowel decontamination does not alter hepatic regeneration in rats

The purpose of the present study was to determine whether changes to the gut flora that occur following norfloxacin-induced selective bowel decontamination alter hepatic regenerative activity. Adult rats (n = 6 per group) were treated with norfloxacin (10 mg/day) or vehicle for 10 days before 70% pa...

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Published inGastroenterology (New York, N.Y. 1943) Vol. 102; no. 4 Pt 1; p. 1403
Main Authors MacIntosh, E L, Gauthier, T, Harding, G K, Minuk, G Y
Format Journal Article
LanguageEnglish
Published United States 01.04.1992
Subjects
Animals
Bacterial Physiological Phenomena
Intestines - microbiology
Liver Regeneration
Male
Norfloxacin - pharmacology
Putrescine - physiology
Rats
Rats, Inbred Strains
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Summary:The purpose of the present study was to determine whether changes to the gut flora that occur following norfloxacin-induced selective bowel decontamination alter hepatic regenerative activity. Adult rats (n = 6 per group) were treated with norfloxacin (10 mg/day) or vehicle for 10 days before 70% partial hepatectomy. Hepatic regenerative activity was determined 24 hours after surgery by documenting restitution of liver mass, [3H]thymidine incorporation into DNA, and ornithine decarboxylase activity in the liver. The results of the study revealed that hepatic regeneration was unaffected by norfloxacin therapy. Thus, selective bowel decontamination with norfloxacin does not alter hepatic regenerative activity following partial hepatectomy in the rat.
ISSN:0016-5085
DOI:10.1016/0016-5085(92)90785-W