Regulation by glucose availability of tension development and electrical activity in fetal and neonatal rat hearts

The aim of the present article was to study if changes in glucose availability modify the functional activity of the glucose-dependent developing heart. Our data indicate that a decrease in glucose availability increases tension development and action potential duration at early fetal stages. This f...

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Bibliographic Details
Published inBiology of the neonate Vol. 66; no. 4; p. 221
Main Authors Guarner, V, Hernández, E H, Moreno, S J, Huerto, R, Gorostiza, P, Valenzuela, F
Format Journal Article
LanguageEnglish
Published Switzerland 1994
Subjects
Action Potentials - drug effects
Action Potentials - physiology
Animals
Animals, Newborn
Fetal Heart - drug effects
Fetal Heart - growth & development
Fetal Heart - physiology
Glucose - metabolism
Glucose - pharmacology
Heart Rate - drug effects
Heart Rate - physiology
Isometric Contraction - drug effects
Isometric Contraction - physiology
Rats
Rats, Wistar
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Summary:The aim of the present article was to study if changes in glucose availability modify the functional activity of the glucose-dependent developing heart. Our data indicate that a decrease in glucose availability increases tension development and action potential duration at early fetal stages. This fact could probably be explained by the enhancement of Ca2+ movements that regulate the number and turnover rate of membrane glucose transporters in muscle cells. The sensitivity to glucose availability decreases postnatally as the heart becomes fatty acid-dependent.
ISSN:0006-3126
DOI:10.1159/000244111